HENRY S. WENTZ, M.D.; HARVEY H. SEIPLE, M.D., F.A.C.P.
Two cases are presented—the first a syndrome of ulceromembranous stomatitis, purulent conjunctivitis, urethritis, and signs of constitutional toxicity; the second an eruptive bullous type febrile disease associated with stomatitis and ophthalmia. Both cases conform to the picture described by Stevens and Johnson. Stevens and Johnson3 in 1922 felt that their syndrome of an eruptive febrile disease associated with stomatitis and purulent conjunctivitis was a distinct clinical entity. Controversy exists, however, as to whether the syndrome should be differentiated from erythema multiforme exsudativum.
Fletcher and Harris1 in 1945 and Keil2 in 1940 have presented excellent historical reviews. Erythemas were first described
WENTZ HS, SEIPLE HH. STEVENS-JOHNSON SYNDROME, A VARIATION OF ERYTHEMA MULTIFORME EXSUDATIVUM (HEBRA): A REPORT OF TWO CASES1. Ann Intern Med. ;26:277–283. doi: 10.7326/0003-4819-26-2-277
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Published: Ann Intern Med. 1947;26(2):277-283.
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