H. A. GRUBSCHMIDT, M.D.; G. C. GRAHAM, M.D.; E. C. JESSUP, M.D., F.A.C.P.
Pratt-Thomas in 19456 reviewed 184 cases of fulminating meningococcemia with eight recoveries. Prior to 1940, all cases were uniformly fatal.
This is a case of Waterhouse-Friderichsen syndrome in a 17 year old white female who fulfilled practically all the clinical criteria and, in addition, yielded meningococci on blood culture. She developed gangrene of three extremities and bilateral ulnar nerve paralysis but recovered. The case presents several unusual features.
The patient was a 17 year old white female waitress who entered Meadowbrook Hospital on Oct. 12, 1945, with a chief complaint of chills and fever of several hours' duration.
GRUBSCHMIDT HA, GRAHAM GC, JESSUP EC. A CASE OF FULMINATING MENINGOCOCCEMIA EXHIBITING THE WATERHOUSE-FRIDERICHSEN SYNDROME AND DEMONSTRATING THE VALUE OF CORTICAL EXTRACT ADMINISTRATION1. Ann Intern Med. ;26:294–304. doi: 10.7326/0003-4819-26-2-294
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Published: Ann Intern Med. 1947;26(2):294-304.
Adrenal Disorders, CNS Infections, Endocrine and Metabolism, Infectious Disease, Multi-Organ Failure and Sepsis.
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