GEORGE R. MINOT, F.A.C.P.; F. H. L. TAYLOR
The beneficial effect of whole blood transfusion in hemophilia has been recognized for over 30 years. The marked fall in the coagulation time following the transfusion of normal blood was attributed in 1916 by Minot and Lee1 to the platelets. Patek and Stetson reinvestigated the problem in 1936. They confirmed the findings of Minot and Lee but showed that plasma free of formed elements including blood platelets had an effect similar to that of whole blood. Patek and Stetson proposed the thesis that the beneficial effect of whole blood transfusion in hemophilia was due to a factor or factors residing
GEORGE R. MINOT, F. H. L. TAYLOR. HEMOPHILIA: THE CLINICAL USE OF ANTIHEMOPHILIC GLOBULIN(HEMOPHILIA: THE CLINICAL USE OF ANTIHEMOPHILIC GLOBULIN*). Ann Intern Med. 1947;26:363–367. doi: 10.7326/0003-4819-26-3-363
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Published: Ann Intern Med. 1947;26(3):363-367.
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