CHARLES D. MARPLE, M.D.
Visceral leishmaniasis (kala-azar) is a chronic and, in untreated cases, a highly fatal infectious disease characterized by a persistent fever of an alternating, remittent, or intermittent type, progressive weight loss, weakness and emaciation, progressive anemia, splenomegaly and hepatomegaly, severe reduction of the leukocytes, particularly of the granulocytes, and by the demonstrable presence of the causative parasite in the spleen and bone marrow. The disease is produced by the protozoan, Leishmania donovani which is transmitted from person to person by the bite of one or more species of blood sucking sandflies of the genus phlebotomus.1 There is a possibility that the
MARPLE CD. VISCERAL LEISHMANIASIS (KALA-AZAR): REPORT OF A CASE(VISCERAL LEISHMANIASIS (KALA-AZAR): REPORT OF A CASE*). Ann Intern Med. 1947;26:787–795. doi: 10.7326/0003-4819-26-5-787
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Published: Ann Intern Med. 1947;26(5):787-795.
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