GEORGE L. WALDBOTT, M.D., F.A.C.P.
The classification of patients with bronchial asthma into two groups, namely, extrinsic and intrinsic, was first advocated by Walker1 in 1918. When the patients exhibited positive skin reactions, the disease was supposedly associated with external causative agents; in patients with negative reactions, so-called intrinsic causes, especially sensitivity to bacteria, were held responsible. Rackemann2 reported in 1927 that among 1,074 asthmatic patients there were an equal number of extrinsic and intrinsic cases. These investigators did not enlarge upon the clinical manifestations or pathological lesions in order to substantiate their classification which is accepted by most authorities. Since less reliance is now
WALDBOTT GL. IS THERE AN INTRINSIC ASTHMA?1. Ann Intern Med. ;26:863–872. doi: 10.7326/0003-4819-26-6-863
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Published: Ann Intern Med. 1947;26(6):863-872.
Asthma, Pulmonary/Critical Care.
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