J. C. SNYDER, M.D.; A. YEOMANS, M.D.; D. H. CLEMENT, M.D.; E. S. MURRAY, M.D.; C. J. D. ZARAFONETIS, M.D.; N. A. TIERNEY, M.D.
The therapeutic effect of para-aminobenzoic acid (PABA) in experimental murine typhus infection of white mice was reported in 1942.1 Subsequently, evidence bearing on the action of PABA in experimental rickettsial infections has been obtained in several laboratories. In the yolk sac membrane of developing chick embryos, PABA or its sodium salt inhibits the multiplication of Rickettsia mooseri,2, 3R. prowazeki,2, 4, 5R. orientalis,5 and Dermacentroxenus rickettsi.4 The mortality in experimental rickettsial infections in white mice,1, 6 gerbilles,7, 8, 9 cotton rats,10 and guinea pigs11 is considerably reduced by PABA.
In 1944 a favorable therapeutic effect from the administration of
SNYDER JC, YEOMANS A, CLEMENT DH, MURRAY ES, ZARAFONETIS CJD, TIERNEY NA. FURTHER OBSERVATIONS ON THE TREATMENT OF TYPHUS FEVER WITH PARA-AMINOBENZOIC ACID1. Ann Intern Med. ;27:1–27. doi: 10.7326/0003-4819-27-1-1
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Published: Ann Intern Med. 1947;27(1):1-27.
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