ROBERT M. CRAIG, M.D.; GEORGE X. SCHWEMLEIN, M.D.; ROBERT L. BARTON, M.D.; THEODORE J. BAUER, M.D.; HERMAN N. BUNDESEN, M.D., F.A.C.P.
The problem of time-dose relationship in the treatment of early syphilis has been foremost in the investigation of this mode of therapy. It has been established that doses of less than 1.2 million units of penicillin were inadequate as measured by the relapse rate.1, 2
The use of a total dose of 1.2 million units of penicillin administered over different time periods, and the combination of this amount with artificial fever therapy (hypertherm) was delegated to this Center by the National Research Council.
The present report concerns only the group of patients treated by the following schedule: each patient received
CRAIG RM, SCHWEMLEIN GX, BARTON RL, BAUER TJ, BUNDESEN HN. PENICILLIN IN THE TREATMENT OF EARLY SYPHILIS, 429 PATIENTS TREATED WITH 1,200,000 UNITS IN 90 HOURS1. Ann Intern Med. 1947;27:225–230. doi: 10.7326/0003-4819-27-2-225
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Published: Ann Intern Med. 1947;27(2):225-230.
Infectious Disease, Sexually Transmitted Infections.
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