C. LOCKARD CONLEY; RODNEY C. LARCOM JR.
Banti, in describing the syndrome which bears his name, attributed the condition to an unknown toxin acting primarily on the spleen. This concept was questioned as early as 1904 by Dock and Warthin,1 who described two cases of Banti's syndrome associated with stenosis and calcification of the portal vein. These investigators believed that the histological changes in the spleens of these cases could be explained by prolonged passive congestion and suggested the possibility that the clinical picture might be caused by portal vein stenosis. Subsequently Dürr2 observed that sections of the spleens from Banti's original cases showed pathological changes indistinguishable
CONLEY CL, LARCOM RC. THE ETIOLOGY OF BANTI'S SYNDROME; FURTHER SUPPORT OF THE "CONGESTIVE SPLENOMEGALY" HYPOTHESIS1. Ann Intern Med. ;27:289–293. doi: 10.7326/0003-4819-27-2-289
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Published: Ann Intern Med. 1947;27(2):289-293.
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