NORMAN H. ISAACSON, M.D.; SAMUEL D. SPATT, M.D.; DAVID M. GRAYZEL, M.D., Ph.D.
In 1832 Hodgkin1 called attention to the existence of a disease characterized by progressive enlargement of the lymph nodes and associated in many instances with enlargement of the spleen. Seventy-five years later Reed2 stated "we know of no case where the pathological anatomy was described in sufficient detail to permit of a positive diagnosis in which the disease commenced elsewhere than in the lymph nodes." Even today most medical authors deny the existence of a primary splenic form of the disease.
Symmers,3 however, in 1909 described a case of an 18 year old girl with recurrent chills and fever and
ISAACSON NH, SPATT SD, GRAYZEL DM. PRIMARY SPLENIC HODGKIN'S DISEASE WITHOUT LYMPH NODE INVOLVEMENT(PRIMARY SPLENIC HODGKIN'S DISEASE WITHOUT LYMPH NODE INVOLVEMENT*). Ann Intern Med. 1947;27:294–301. doi: 10.7326/0003-4819-27-2-294
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Published: Ann Intern Med. 1947;27(2):294-301.
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