EDGAR V. ALLEN, M.D., F.A.C.P.; EDGAR A. HINES JR., M.D., F.A.C.P.; WALTER F. KVALE, M.D., F.A.C.P.; NELSON W. BARKER, M.D., F.A.C.P.
Six years have elapsed since the first report on the clinical use of dicumarol.1 Since that time there have been a number of clinical reports by ourselves and others. The literature has been reviewed previously.2, 3 It is the purpose of this presentation to consider this new therapeutic tool in the light of six years' experience.
Dicumarol is a pure chemical compound which may be recovered from spoiled sweet clover and which has been prepared synthetically. The discovery that it is the agent which causes spoiled sweet clover disease of animals which is characterized by hemorrhage, the determination of its
ALLEN EV, HINES EA, KVALE WF, BARKER NW. THE USE OF DICUMAROL AS AN ANTICOAGULANT: EXPERIENCE IN 2,307 CASES1. Ann Intern Med. ;27:371–381. doi: 10.7326/0003-4819-27-3-371
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Published: Ann Intern Med. 1947;27(3):371-381.
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