J. GARROTT ALLEN; GEORGE BOGARDUS; L. O. JACOBSON; CHARLES L. SPURR
In a previous communication it was reported that in irradiation hemorrhage (roentgen-ray) an anticoagulant was present in the blood.1 This anticoagulant was indistinguishable from heparin. The hemorrhagic tendency in dogs could be prevented or stopped temporarily by the intravenous injection of protamine sulfate or toluidine blue. Both of these substances are capable of binding heparin and rendering it biologically inactive so far as its anticoagulant properties are concerned. They do not appear to affect any other phase of the clotting mechanism except to act as anticoagulants when present in excess.1 These agents were effective even in the face of marked
ALLEN JG, BOGARDUS G, JACOBSON LO, SPURR CL. SOME OBSERVATIONS ON BLEEDING TENDENCY IN THROMBOCYTOPENIC PURPURA1. Ann Intern Med. ;27:382–395. doi: 10.7326/0003-4819-27-3-382
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Published: Ann Intern Med. 1947;27(3):382-395.
Coagulopathies, Hematology/Oncology, Platelet Disorders.
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