CHARLES A. L. STEPHENS JR., M.D.; ALICE L. BORDEN, M.S.; W. PAUL HOLBROOK, M.D., F.A.C.P.; DONALD F. HILL, M.D., F.A.C.P.
It is well established on sound evidence that rheumatoid arthritis is a systemic disease.1, 2, 3, 4 The most dramatic manifestation is usually a polyarthritis. However, associated fever, anorexia, weight loss, muscle atrophy, iritis, elevated sedimentation rate, and anemia, and the often dramatic relief with jaundice,5, 6 or pregnancy,7 prove conclusively its generalized nature.
Of all the associated symptoms of rheumatoid arthritis almost consistently present is a hypochromic microcytic anemia of an appreciable degree.8, 9, 10 Of 50 cases of rheumatoid arthritis chosen at random from our files the average initial hemoglobin before treatment was 11.04 grams, the average
STEPHENS CAL, BORDEN AL, HOLBROOK WP, HILL DF. THE USE OF FOLIC ACID IN THE TREATMENT OF ANEMIA OF RHEUMATOID ARTHRITIS—A PRELIMINARY REPORT1. Ann Intern Med. 1947;27:420–432. doi: 10.7326/0003-4819-27-3-420
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Published: Ann Intern Med. 1947;27(3):420-432.
Hematology/Oncology, Red Cell Disorders, Rheumatoid Arthritis, Rheumatology.
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