MAXWELL M. WINTROBE, F.A.C.P.; CHARLES M. HUGULEY JR.; MARGARET T. MCLENNAN; LUCIO PENNA DE CARVALHO LIMA
The nitrogen mustards differ from the mustard war gas only in that nitrogen replaces sulfur. Study of the biological effects of the nitrogen mustards has revealed that they parallel and are almost identical with the biological effects of radiant energy.
The most important properties of the beta chloroethyl amines (nitrogen mustards) are outlined in table 1. While these substances are stable and
unreactive in dry form, in aqueous solution a rapid change takes place. The beta carbon forms a ring with the nitrogen to make a quaternary ammonium base, with the release of chloride ion. The quaternary ammonium ion is
WINTROBE MM, HUGULEY CM, MCLENNAN MT, DE CARVALHO LIMA LP. NITROGEN MUSTARD AS A THERAPEUTIC AGENT FOR HODGKIN'S DISEASE, LYMPHOSARCOMA AND LEUKEMIA1. Ann Intern Med. ;27:529–540. doi: 10.7326/0003-4819-27-4-529
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Published: Ann Intern Med. 1947;27(4):529-540.
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