P. W. C.
The sulfur and nitrogen mustards, because of their use as warfare agents, have been subjected to intensive study, both as to their chemical nature and their action on the tissues. Although originally employed primarily because of their local irritant and vesicant action on the skin and mucous membranes, it was soon recognized that when absorbed they exert a toxic action on a variety of tissues.
In animals subjected to toxic doses,1 the tissues most severely involved are the mucosa of the gastrointestinal tract and the hemopoietic tissues. There is vacuolization and swelling of the nuclei of the gastrointestinal epithelium, followed
C. PW. THE THERAPEUTIC USE OF NITROGEN MUSTARDS. Ann Intern Med. ;27:641–645. doi: 10.7326/0003-4819-27-4-641
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Published: Ann Intern Med. 1947;27(4):641-645.
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