PAUL KLEMPERER, M.D.
In 1872 when Kaposi1 published his first report of acute lupus erythematosus, medicine was still dominated by the pathologic-anatomic doctrine that disease is the result of alterations of bodily structure. Today the study of pathogenesis aims at a full comprehension and integration of all the factors of the external and internal environment which bring about that altered state of life, called disease. Inquiry into the genesis of a disease can no longer be content with the mere perception of structural alterations. Yet the definition of most maladies still depends upon an exact knowledge of characteristic organ and tissue changes. Therefore,
KLEMPERER P. THE PATHOGENESIS OF LUPUS ERYTHEMATOSUS AND ALLIED CONDITIONS1. Ann Intern Med. ;28:1–11. doi: 10.7326/0003-4819-28-1-1
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Published: Ann Intern Med. 1948;28(1):1-11.
Lupus Erythematosus, Rheumatology.
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