Penicillin is actively bactericidal in vitro1, 2, 3, 4, 5, 6, 7; and although the body's cellular or humoral defense mechanisms probably play a contributory rôle in vivo, that direct bactericidal action may be largely responsible for the therapeutic activity of the drug.
The susceptibility of a given organism to penicillin may be defined in terms of three concentrations (figures 1 and 2; cf. also2, 6, 7). The first is that which suffices only to reduce the normal rate of multiplication, and is illustrated by curve 0.004 in figure 1 and point A
EAGLE H. SPECULATIONS AS TO THE THERAPEUTIC SIGNIFICANCE OF THE PENICILLIN BLOOD LEVEL1. Ann Intern Med. ;28:260–278. doi: 10.7326/0003-4819-28-2-260
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Published: Ann Intern Med. 1948;28(2):260-278.
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