M. S. S.
The control of Addisonian pernicious anemia by the use of liver undoubtedly represents one of the most notable contributions of modern medicine to the welfare of mankind. Castle's hypothesis, 1 conceived as a result of a series of ingenious clinical investigations, supplied the theoretical basis for an understanding of the mode of development of this and related macrocytic anemias. The effectiveness of extracts of liver in a variety of clinical entities has usually been explained by reference to this "unitarian" hypothesis which was based upon the interaction of an "extrinsic" dietary factor with an "intrinsic" gastric factor leading to the
S. MS. THE PRESENT STATUS OF FOLIC ACID IN THE THERAPY OF MACROCYTIC ANEMIA. Ann Intern Med. ;28:461–465. doi: 10.7326/0003-4819-28-2-461
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Published: Ann Intern Med. 1948;28(2):461-465.
Hematology/Oncology, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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