SAMUEL J. PRIGAL, M.D.
Evidence presented below indicates that the lungs, because of their anatomic structure, can serve as an excellent means for the introduction of certain medications, in aerosol form,4 intended for systemic action. Aerosol therapy differs from inhalational therapy in which gases have been employed in the treatment of cardiorespiratory diseases. Gas therapy is now an established procedure (Barach,1 Segal,2) and is beyond the scope of this paper.
In recent years, medicated aerosol therapy has been advocated for the treatment of pulmonary diseases. Thus, for asthma, epinephrin aerosol has been used either by hand bulb nebulizer,3 or by the continuous inhalation method
PRIGAL SJ. STUDIES WITH MEDICATED AEROSOLS: THE USE OF THE LUNGS AS A PORTAL FOR THE INTRODUCTION OF THERAPEUTIC AGENTS FOR SYSTEMIC EFFECT12. Ann Intern Med. 1948;28:814–825. doi: 10.7326/0003-4819-28-4-814
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Published: Ann Intern Med. 1948;28(4):814-825.
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