GERALD KLATSKIN, M.D.; HARRY FRIEDMAN, M.D.
Emetine is an important drug in the treatment of amebiasis, even though it frequently fails to cure the intestinal form of the disease. It is indispensable in the management of amebic hepatitis and abscess,1 it controls the dysenteric symptoms most effectively, and there is evidence to suggest that it improves the end results of treatment in intestinal amebiasis when used in conjunction with other amebicides.2 Yet, fear of toxicity has led to the employment of ineffective doses and, in some instances, to the complete abandonment of emetine.23 There is evidence to indicate, however, that moderate to large doses may be
KLATSKIN G, FRIEDMAN H. EMETINE TOXICITY IN MAN: STUDIES ON THE NATURE OF EARLY TOXIC MANIFESTATIONS, THEIR RELATION TO THE DOSE LEVEL, AND THEIR SIGNIFICANCE IN DETERMINING SAFE DOSAGE(EMETINE TOXICITY IN MAN: STUDIES ON THE NATURE OF EARLY TOXIC MANIFESTATIONS, THEIR RELATION TO THE DOSE LEVEL, AND THEIR SIGNIFICANCE IN DETERMINING SAFE DOSAGE*). Ann Intern Med. 1948;28:892–915. doi: 10.7326/0003-4819-28-5-892
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Published: Ann Intern Med. 1948;28(5):892-915.
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