HYMAN LEVY, M.D.; ERNST P. BOAS, M.D.
Enthusiastic reports1, 2 on the value of vitamin E (alpha-tocopherol) in the treatment of certain forms of heart disease warrant further trial with this substance. Cardiac failure has been reported in cattle fed with vitamin E-free rations.3 Such animals exhibit progressive electrocardiographic abnormalities, are prone to sudden death, and sections of their heart muscle show microscopical evidences of atrophy and scarring of muscle fibers. In our small but carefully studied and controlled group of patients, we have been unable to reproduce the therapeutic improvement previously reported. In fact, in chronic angina pectoris due to coronary sclerosis, in heart failure secondary
LEVY H, BOAS EP. VITAMIN E IN HEART DISEASE1. Ann Intern Med. ;28:1117–1124. doi: 10.7326/0003-4819-28-6-1117
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Published: Ann Intern Med. 1948;28(6):1117-1124.
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