H. D. BRUNER, M.D., PH.D.; MARY H. GIBBON; MILES D. MCCARTHY, PH.D.; ROBERT D. BOCHE, PH.D.; TIMOTHY R. TALBOT JR., M.D.; JOHN S. LOCKWOOD, M.D.; GEORGE B. SANDERS, M.D.
Following exposure to phosgene, the transudation of plasma into the pulmonary alveoli leads to two functional derangements, either of which is potentially lethal.1, 2, 3 One is the obstruction to pulmonary gaseous exchange due to the physical presence of this fluid in the alveoli and eventually in the bronchioles; the development and magnitude of this lesion can be evaluated by observing the arterial oxygen saturation. The second is loss of circulating plasma volume which results in a hemodynamic state very similar to secondary or surgical shock. The accompanying hemoconcentration may be so extreme that the raised blood viscosity seriously impedes
BRUNER HD, GIBBON MH, MCCARTHY MD, BOCHE RD, TALBOT TR, LOCKWOOD JS, et al. STUDIES ON EXPERIMENTAL PHOSGENE POISONING V. INFUSIONS IN THE TREATMENT OF EXPERIMENTAL PHOSGENE POISONING1. Ann Intern Med. 1948;28:1125–1131. doi: 10.7326/0003-4819-28-6-1125
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Published: Ann Intern Med. 1948;28(6):1125-1131.
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