RALPH LEE FISHER, A.B., M.D., F.A.C.P.; MORRIS ZUKERMAN, A.B., M.D.
We wish to present a review of our experience with 24 patients treated with a massive dosage of penicillin by continuous intramuscular infusion.
The dose varied from 500,000 to 2,000,000 units of penicillin administered daily for a period of three to 19 days. The first nine patients were given crude penicillin and the last 15 penicillin G.
Technic of Administration: The penicillin was dissolved in 500 c.c. of 5 per cent glucose in water. A No. 20 gauge spinal needle was inserted in the lateral aspect of the thigh after infiltration with 1 per cent procaine hydrochloride. Ten c.c. of
FISHER RL, ZUKERMAN M. MASSIVE DOSAGE OF PENICILLIN ADMINISTERED BY CONTINUOUS INTRAMUSCULAR INFUSION1. Ann Intern Med. ;28:1143–1149. doi: 10.7326/0003-4819-28-6-1143
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Published: Ann Intern Med. 1948;28(6):1143-1149.
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