GEORGE HOLLANDER, M.D.; HARRY MANDELBAUM, M.D., F.A.C.P.
Effective and striking results in the treatment of angina pectoris have been obtained with total thyroidectomy.1, 2 Its shortcomings—the risk of surgery, subsequent complications and irreparable loss of thyroid function—have limited its use to patients with a fair life expectancy who are adequate surgical risks. At the present time, drugs which selectively act to block the formation of active thyroid hormone to give rise to a reversible, chemical thyroidectomy, include radioactive iodine and the thiouracil group. In many, these are a medical substitute for surgery, without its discomfort and occasional mortality. The newer, more powerful and less toxic derivatives of
HOLLANDER G, MANDELBAUM H. THE TREATMENT OF ANGINA PECTORIS WITH PROPYLTHIOURACIL1. Ann Intern Med. 1948;28:1150–1156. doi: 10.7326/0003-4819-28-6-1150
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Published: Ann Intern Med. 1948;28(6):1150-1156.
Cardiology, Coronary Heart Disease.
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