P. W. C.
Since the early publications of Chauffard it has been well known that patients with this disease are prone to suffer acute exacerbations which are commonly termed hemolytic crises—"crises de déglobulization." During such periods there is usually fever, malaise, prostration, shortness of breath, and often acute abdominal pain with anorexia and vomiting. There is a rapid increase in the anemia, so that the red cell count and hemoglobin are often reduced to half of the original figures within a week or less. In occasional cases this may progress to a fatal termination, but as a rule after one to two weeks
C. PW. THE MECHANISM OF THE CRISES IN FAMILIAL HEMOLYTIC JAUNDICE. Ann Intern Med. ;28:1193–1196. doi: 10.7326/0003-4819-28-6-1193
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Published: Ann Intern Med. 1948;28(6):1193-1196.
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