SAMUEL WALDMAN, M.D.; LOUIS PELNER, M.D.
Neostigmine has been used successfully in the treatment of supraventricular tachycardias.1, 2, 3, 4, 5, 6 Its action is predicated upon the cholinergic activity of this drug, which in these cases effects its often dramatic action through the vagus nerve. By inhibiting the action of cholinesterase at the myoneural junction, it permits the action of choline to exert its full effect. Study of the action of neostigmine in tachycardias has made it evident that its action is of somewhat specific value in treating sinus tachycardias, paroxysmal auricular tachycardias, and paroxysmal nodal tachycardias. By correcting the chemical and physical imbalance which
WALDMAN S, PELNER L. THE ACTION OF NEOSTIGMINE IN SUPRAVENTRICULAR TACHYCARDIAS1. Ann Intern Med. ;29:53–63. doi: 10.7326/0003-4819-29-1-53
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Published: Ann Intern Med. 1948;29(1):53-63.
Cardiology, Rhythm Disorders and Devices.
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