J. BURNS AMBERSON, F.A.C.P.; WILLIAM H. STEARNS
The effects of streptomycin administered to tuberculous patients have been shown to be strikingly beneficial in some phases of the disease, equivocal in some, and quite insignificant in others. Toxic damage by the antibiotic has been a frequent occurrence but this can be minimized by limiting the dose and the length of treatment. A more serious disadvantage, insurmountable thus far, is the development of bacterial resistance to streptomycin which often nullifies its further therapeutic action. While its potency against tuberculosis is unprecedented by any other drug, there are already some manifest limitations of its effectiveness. It has not altered the
AMBERSON JB, STEARNS WH. STREPTOMYCIN IN THE TREATMENT OF TUBERCULOSIS1. Ann Intern Med. ;29:221–228. doi: 10.7326/0003-4819-29-2-221
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Published: Ann Intern Med. 1948;29(2):221-228.
Infectious Disease, Mycobacterial Infections.
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