SOL SMITH, M.D.; E. S. MCCABE, M.D.
In 1924 Felty1 described the syndrome of chronic rheumatoid arthritis associated with splenomegaly and leukopenia. He was preceded by Still2 who, in 1897, reported a disease of children characterized by chronic joint disease, splenomegaly and leukocytosis. In 1932 Hanrahan and Miller3 performed the first splenectomy for Felty's syndrome. The operation was done primarily to relieve the patient of the discomforts of the enlarged spleen and to correct the leukopenia. What reasoning led them to expect the latter is obscure. Because of the good result obtained by Hanrahan and Miller, Craven4 carried out the same operation in his patient in 1934.
SMITH S, MCCABE ES. PRIMARY SPLENIC NEUTROPENIA WITH ARTHRITIS (SO-CALLED FELTY'S SYNDROME). ITS TREATMENT BY SPLENECTOMY1. Ann Intern Med. ;29:445–455. doi: 10.7326/0003-4819-29-3-445
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Published: Ann Intern Med. 1948;29(3):445-455.
Rheumatoid Arthritis, Rheumatology.
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