HANS POPPER, M.D., Ph.D., F.A.C.P.; FREDERICK STEIGMANN, M.D., M.S., F.A.C.P.
Despite the great strides of laboratory medicine in the past two decades and the subsequent elaboration of many liver function tests, the jaundiced patient still presents today a challenging diagnostic problem. There is little difficulty in recognizing the hemolytic variety of jaundice (retention type) primarily by the absence of bile from the urine, the low or absent direct serum bilirubin and evidence of hemolysis. However, to differentiate the two types of regurgitation jaundice, the medical (due to acute or chronic hepatitis or to cirrhosis) from the surgical (due to stones, tumors or strictures), is often difficult. Even the experienced clinician
POPPER H, STEIGMANN F. DIFFERENTIAL DIAGNOSIS BETWEEN MEDICAL AND SURGICAL JAUNDICE BY LABORATORY TESTS1. Ann Intern Med. 1948;29:469–487. doi: 10.7326/0003-4819-29-3-469
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Published: Ann Intern Med. 1948;29(3):469-487.
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