JACK D. KIRSHBAUM, M.D., F.A.C.P.; BERNARD M. CHAPMAN, M.D.
Cases of acromegaly are infrequently encountered and when seen are looked upon as curiosities. The clinical syndrome of acromegaly was first described in 1886 by Pierre Marie, and the following year Minkowski1 suggested that the disease was caused by derangement of the hypophysis cerebri. It is well known that acromegaly is associated with eosinophilic adenomas of the anterior lobe of the hypophysis. However, many cases of eosinophilic adenoma of the hypophysis do not manifest acromegalic features nor other endocrine disturbances clinically.
Although most writers2 state that acromegaly occurs usually between the ages of 20 and 30 years, the author's cases
KIRSHBAUM JD, CHAPMAN BM. SUBARACHNOID HEMORRHAGE SECONDARY TO A TUMOR OF THE HYPOPHYSIS WITH ACROMEGALY1. Ann Intern Med. ;29:536–540. doi: 10.7326/0003-4819-29-3-536
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Published: Ann Intern Med. 1948;29(3):536-540.
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