JOSEPH A. EPSTEIN, M.D.; ISAAC H. RICHTER, M.D.
In this communication we wish to present a case which clinically and pathologically conforms to the disease entity known as "Essential Thrombophilia." In 1937, Nygaard and Brown defined this syndrome and reported five cases in which thrombosis occurred in the vessels of the extremities and in the brain, kidney and heart. The thrombosis occurred without any previously known disease of the vessels involved such as is seen in thromboangiitis obliterans and in arteriosclerosis. The pathological changes in the vessels were minimal and of a non-reacting type. Thrombosis was evident without signs of disease in the intima and in the other
EPSTEIN JA, RICHTER IH. ESSENTIAL THROMBOPHILIA: REPORT OF A CASE1. Ann Intern Med. ;29:545–549. doi: 10.7326/0003-4819-29-3-545
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Published: Ann Intern Med. 1948;29(3):545-549.
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