BRUCE R. POWERS
Nicotinic acid has come into widespread use not only because of its importance in the vitamin B complex but also because of its side action, vasodilatation. It is generally considered to be of low toxicity either given by mouth or by vein and few untoward reactions have been reported. Some patients complain of the flush, itching, and sense of heat following either oral or intravenous administration and when doses sufficiently large to produce these signs of vasodilatation are given the patient should be told beforehand that the above phenomena will appear. These signs are desired and do not constitute toxic
POWERS BR. CIRCULATORY COLLAPSE FOLLOWING INTRAVENOUS ADMINISTRATION OF NICOTINIC ACID (NIACIN)1. Ann Intern Med. 1948;29:558–560. doi: 10.7326/0003-4819-29-3-558
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Published: Ann Intern Med. 1948;29(3):558-560.
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