CHARLES EDWARD SMITH, M.D.; RODNEY RAU BEARD, M.D.; MARGARET TAIKO SAITO, A.B.
It is now accepted that human infections of Coccidioides immitis are usually acquired by inhaling the chlamydospores and arthrospores of the fungus. Occasionally the portal of entry may be by abrasions or lacerations.8 After an incubation period ranging from one to three weeks, symptoms develop in approximately 40 per cent of infected males.37 However, three-fifths of the infections are completely asymptomatic. The pneumonic or respiratory symptoms which occur in two-fifths are of varying degrees of severity. Among females an increased frequency of erythema nodosum results in a somewhat higher proportion of clinically manifest disease. This erythema nodosum is a complication
SMITH CE, BEARD RR, SAITO MT. PATHOGENESIS OF COCCIDIOIDOMYCOSIS WITH SPECIAL REFERENCE TO PULMONARY CAVITATION1. Ann Intern Med. 1948;29:623–655. doi: 10.7326/0003-4819-29-4-623
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Published: Ann Intern Med. 1948;29(4):623-655.
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