LOUIS H. SIGLER, M.D., F.A.C.P.
It has been known for hundreds of years that pressure applied to the carotid sinus region may result in unconsciousness and convulsions. According to Ask-Upmark,1 the Assyrians used this method to dull pain during the rites of circumcision. Perry2 observed this phenomenon in 1779. The mechanism of its production, however, was not clearly understood until the pioneer work of Hering3 and of Heymans.4 These authors demonstrated that stimulation of the carotid sinus region results in a number of reflexes, the most prominent of which are those of cardioinhibition, vasodepression, and disturbances in respiration. This was followed by the work of
SIGLER LH. SUBJECTIVE MANIFESTATIONS OF THE HYPERACTIVE CAROTID SINUS REFLEX(SUBJECTIVE MANIFESTATIONS OF THE HYPERACTIVE CAROTID SINUS REFLEX*). Ann Intern Med. 1948;29:687–697. doi: 10.7326/0003-4819-29-4-687
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Published: Ann Intern Med. 1948;29(4):687-697.
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