HARLEY E. CLUXTON JR., M.D.; WARREN A. BENNETT, M.D.; EDWIN J. KEPLER, M.D., F.A.C.P.
Anterior pituitary insufficiency (panhypopituitarism) may result from any pathologic process that destroys the anterior lobe. The most common lesion is the chromophobe tumor. Less frequently, other nonfunctioning neoplastic lesions, granulomas, chronic infections, atrophy, necrosis, hemorrhage, infarction or miscellaneous vascular disturbances account for pituitary failure. The terms "Simmonds' disease" and "Simmonds' cachexia"1 have been applied, often indiscriminately, either to pituitary necrosis that occurs postpartum or to cachectic patients having, or thought to have, anterior pituitary insufficiency for other reasons. Clinically, the symptom complex that characterizes postpartum pituitary necrosis is essentially the same as that which occurs in conjunction with any other
CLUXTON HE, BENNETT WA, KEPLER EJ. ANTERIOR PITUITARY INSUFFICIENCY (PANHYPOPITUITARISM—SIMMONDS' DISEASE), PITUITARY MYXEDEMA AND CONGESTIVE HEART FAILURE (MYXEDEMA HEART); REPORT OF CASE AND FINDINGS AT NECROPSY(ANTERIOR PITUITARY INSUFFICIENCY (PANHYPOPITUITARISM—SIMMONDS' DISEASE), PITUITARY MYXEDEMA AND CONGESTIVE HEART FAILURE (MYXEDEMA HEART); REPORT OF CASE AND FINDINGS AT NECROPSY*). Ann Intern Med. 1948;29:732–745. doi: 10.7326/0003-4819-29-4-732
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Published: Ann Intern Med. 1948;29(4):732-745.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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