C. PHILLIP MILLER, M.D., F.A.C.P.
The development of resistance to the antibiotic drugs is a problem of theoretical interest to the bacteriologist and of practical importance to the clinician.
I should like to describe briefly some experimental studies on the development of bacterial resistance to penicillin and streptomycin and then discuss the clinical implications suggested by these laboratory observations.
Resistance to penicillin can develop in some bacteria, but it usually develops slowly. Meningococcus, for example, has been found to acquire resistance to penicillin if it is repeatedly subcultured onto media containing increasing concentrations of the drug. The graph in figure 1
MILLER CP. BACTERIAL RESISTANCE TO ANTIBIOTICS(BACTERIAL RESISTANCE TO ANTIBIOTICS*). Ann Intern Med. 1948;29:765–774. doi: 10.7326/0003-4819-29-5-765
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Published: Ann Intern Med. 1948;29(5):765-774.
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