RAYMOND K. THOMPSON, M.D.; JOHN A. WAGNER, M.D.; CHRISTIE M. MACLEOD, M.D.
Sickle cell disease was originally described by Herrick1 in 1910, as anemia with sickle-shaped erythrocytes. During a crisis of sickling these characteristic cells become wedged in capillaries, often producing thrombosis. In the past 20 years increasing attention has centered about the histopathology of sickle cell disease, particularly with reference to the vascular thromboses so frequently noted. This vascular occlusive phenomenon results in a protean symptomatology dependent upon the vessels occluded. Although the cerebral manifestations of the disease were undoubtedly previously noted, the first report was that of Sydenstricker, Mulherin, and Houseal2 in 1923. This was followed by isolated case reports.3-22
THOMPSON RK, WAGNER JA, MACLEOD CM. SICKLE CELL DISEASE: REPORT OF A CASE WITH CEREBRAL MANIFESTATIONS IN THE ABSENCE OF ANEMIA1. Ann Intern Med. 1948;29:921–928. doi: 10.7326/0003-4819-29-5-921
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Published: Ann Intern Med. 1948;29(5):921-928.
Hematology/Oncology, Red Cell Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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