JOSEPH C. WATTS, M.D., F.A.C.P.; JACK RUTHBERG, M.D.
Recently a marked increase in the number of cases of poisoning due to barbituric acid derivatives has made an effective antidote or analeptic a matter of paramount importance. The drugs of the barbiturate group have been readily available to the laity, and newspaper publicity, instead of helping the situation, appears actually to have increased the number of cases of attempted suicide from these drugs.
Various antidotes for human barbiturate poisoning have been in use for years. Picrotoxin and coramine (as coriamyrtin) were used as early as 1891-1892.1 Arnett2 administered picrotoxin in 1933 after Maloney, Fitch and Tatum3 had demonstrated its
WATTS JC, RUTHBERG J. CORAMINE (NIKETHAMIDE) IN BARBITURATE POISONING: COMPARISON WITH PICROTOXIN; PRELIMINARY REPORT1. Ann Intern Med. ;29:1104–1114. doi: 10.7326/0003-4819-29-6-1104
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Published: Ann Intern Med. 1948;29(6):1104-1114.
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