P. W. C.
The production of liver extracts which could be administered parenterally to patients with pernicious anemia constituted an important advance in the treatment of this disease. The earlier types of extracts were crude mixtures in which the active substance was present in relatively high dilution. Although the intensive work carried on during the past 15 years has resulted in the production of extracts for therapeutic use of far higher concentration, attempts to isolate the active substance and determine its chemical nature have hitherto been unsuccessful. Such work has been greatly hampered by the lack of any chemical or biological test to
C. PW. FURTHER REFINEMENT OF LIVER EXTRACTS EFFECTIVE IN PERNICIOUS ANEMIA. Ann Intern Med. ;29:1169–1172. doi: 10.7326/0003-4819-29-6-1169
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Published: Ann Intern Med. 1948;29(6):1169-1172.
Hematology/Oncology, Red Cell Disorders.
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