W. O. THOMPSON, M.D., F.A.C.P.
Many substances with androgenic properties have been isolated from the testes, adrenals, blood, and urine, but the most potent androgenic material isolated so far is testosterone. This substance was isolated from the testis by Laqueur and his colleagues in 19351 and was synthesized in the same year by Ruzicka2 and Butenandt.3 Various observations suggest that it is more potent when administered in the form of an ester than when given in the free form. In clinical medicine it is usually administered in the form of the propionate.
Although other androgens have been isolated and prepared synthetically, they are rarely
THOMPSON WO. ANDROGEN THERAPY1. Ann Intern Med. ;30:55–68. doi: 10.7326/0003-4819-30-1-55
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Published: Ann Intern Med. 1949;30(1):55-68.
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