ROBERTO F. ESCAMILLA, M.D., F.A.C.P.
The discovery that extracts of human urine have measurable androgenic and estrogenic effects has stimulated many investigators. Concepts worked out by years of clinical observations seemed possible of more definite proof or disproof. Estimating the values of excretion products of endocrine function in the urine promised a way to study further these established clinical syndromes in the human patient rather than in the experimental animal.
However, bioassay is necessary in many of the determinations. This usually means maintaining animal colonies with all the attendant complications, and the necessity for specially trained personnel. Also various animal species do not react
ESCAMILLA RF. DIAGNOSTIC SIGNIFICANCE OF URINARY HORMONAL ASSAYS: REPORT OF EXPERIENCE WITH MEASUREMENTS OF 17-KETOSTEROIDS AND FOLLICLE STIMULATING HORMONE IN THE URINE(DIAGNOSTIC SIGNIFICANCE OF URINARY HORMONAL ASSAYS: REPORT OF EXPERIENCE WITH MEASUREMENTS OF 17-KETOSTEROIDS AND FOLLICLE STIMULATING HORMONE IN THE URINE*). Ann Intern Med. 1949;30:249–290. doi: 10.7326/0003-4819-30-2-249
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Published: Ann Intern Med. 1949;30(2):249-290.
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