ANDREW H. MEYER, M.D.; W. C. OVERMILLER, M.D.
Medical science has profited from the study of agents used in chemical warfare. Investigation into the mode of action of mustard gas revealed a type of action of sulfur and nitrogen mustards which is unlike that of any other chemical agent and resembles in many ways that of roentgen-rays.1 The effects of the mustards on lymphoid tissue, coupled with the finding that actively proliferating cells are selectively vulnerable to the cytotoxic action of the mustards, led to its use in the treatment of neoplasms of lymphoid tissue. Of the many substances studied, two variants of special importance have emerged: tris
MEYER AH, OVERMILLER WC. THE USE OF A NITROGEN MUSTARD1 IN HODGKIN'S DISEASE AND LYMPHOSARCOMA2. Ann Intern Med. ;30:381–386. doi: 10.7326/0003-4819-30-2-381
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Published: Ann Intern Med. 1949;30(2):381-386.
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