W. Q. WOLFSON, M.D.; C. COHN, M.D.; R. LEVINE, M.D.; E. F. ROSENBERG, M.D., F.A.C.P.; H. D. HUNT, M.D.
The medical literature of the past century contains numerous references to the supposed rôle of the liver in gout.7 through 15, 23, 24, 30, 31, 42, 50, 55, 62, 63, 79 Three types of hypothesis have been presented: (1) that gout results from an isolated disturbance in some hepatic enzyme, (2) that gout results from chronic diffuse hepatic impairment, and (3) that hepatic impairment is a frequent visceral complication of gout. The first hypothesis is as yet difficult to evaluate, since suitable methods of study have only recently become available.31, 32, 33 The latter two hypotheses may be evaluated by
WOLFSON WQ, COHN C, LEVINE R, ROSENBERG EF, HUNT HD. LIVER FUNCTION AND SERUM PROTEIN STRUCTURE IN GOUT1. Ann Intern Med. 1949;30:598–614. doi: 10.7326/0003-4819-30-3-598
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Published: Ann Intern Med. 1949;30(3):598-614.
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