VERN F. DEYKE; MYRON W. FISHER; LYNN A. JAMES; LEROY J. SIDES
Current streptomycin treatment regimens for pulmonary tuberculosis have been dictated largely by streptomycin toxicity and by development of bacterial resistance to this antibiotic. Since the initial utilization of streptomycin as an adjunct to the treatment of tuberculosis,9, 8 the general trends to minimize or eliminate these obstacles have been toward reductions in daily dosage, frequency of administration, and duration of treatment. These trends have effected a reduction of toxicity; however, the latter trend has been utilized to avoid rather than to solve the paramount obstacle of prolonged effective treatment, namely the development of bacterial resistance. This, in our opinion, has
DEYKE VF, FISHER MW, JAMES LA, SIDES LJ. INTERMITTENT DOSAGE SCHEDULES OF STREPTOMYCIN WITH RESULTANT PROLONGED SENSITIVITY OF M. TUBERCULOSIS1. Ann Intern Med. ;30:619–634. doi: 10.7326/0003-4819-30-3-619
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Published: Ann Intern Med. 1949;30(3):619-634.
Infectious Disease, Mycobacterial Infections.
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