WILLIAM G. LEAMAN, M.D., F.A.C.P.; MARIAN B. WIKINGSSON, M.D.; MARIE B. WEBSTER, M.D.; CHRISTOPHER C. SHAW, M.D., F.A.C.P.
Penicillin is the antibiotic of choice in the treatment of subacute bacterial endocarditis1 if the organism is sensitive to the bactericidal action of penicillin.
Adequate daily dosage of penicillin over a sufficiently long period is imperative in obtaining clinical success with antibiotic therapy.2 Insufficient amounts of penicillin may produce a deceptive response, with disappearance of symptoms, drop in temperature and sterile blood cultures, but as soon as such inadequate treatment is discontinued bacteremia promptly returns.3 Another danger inherent in sub-curative therapy is the development of resistance to the antibiotic by the pathogenic organism. Subsequent therapy may require extremely large daily
WILLIAM G. LEAMAN, MARIAN B. WIKINGSSON, MARIE B. WEBSTER, CHRISTOPHER C. SHAW. CARONAMIDE(CARONAMIDE* AND PENICILLIN IN SUBACUTE BACTERIAL ENDOCARDITIS DUE TO STREPTOCOCCUS FAECALIS†) AND PENICILLIN IN SUBACUTE BACTERIAL ENDOCARDITIS DUE TO STREPTOCOCCUS FAECALIS(CARONAMIDE* AND PENICILLIN IN SUBACUTE BACTERIAL ENDOCARDITIS DUE TO STREPTOCOCCUS FAECALIS†). Ann Intern Med. 1949;30:646–654. doi: 10.7326/0003-4819-30-3-646
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Published: Ann Intern Med. 1949;30(3):646-654.
Cardiology, Endocarditis, Infectious Disease, Streptococcal Infections.
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