SHERMAN M. MELLINKOFF, M.D.; ANTHONY V. PISCIOTTA, M.D.
In 1925 Seishiro Iwai and Nin Mei-Sai in Korea described a patient with Raynaud's phenomena in whom chilling of the blood serum caused agglutination of the red cells.1 Since then there have been scattered reports of peripheral vascular disturbances in patients whose blood serum possessed this power of cold hemagglutination. The most recent review of the subject lists 18 such cases and adds a nineteenth.2
In 1943 Stats and Wassermann published an excellent comprehensive analysis of the experimental and clinical significance of cold hemagglutination,3 and several other investigators have discussed this strange phenomenon in its specific connection with vascular disease.1,
MELLINKOFF SM, PISCIOTTA AV. COLD HEMAGGLUTINATION IN PERIPHERAL VASCULAR DISEASE1. Ann Intern Med. ;30:655–662. doi: 10.7326/0003-4819-30-3-655
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Published: Ann Intern Med. 1949;30(3):655-662.
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