JOHN P. DAVIS, M.D., F.A.C.P.; DAVID ROSENBAUM, M.D.
Cold autohemolysis denotes the presence in the blood of an immunologic reactor (autohemolysin), which at low temperatures unites with red cells to produce a hemolytic reaction. Hemoglobinemia and, if hemolysis is sufficiently marked, hemoglobinuria will result.
Paroxysmal hemoglobinuria has been frequently recognized since its first description by Dressler1 in 1854. It is known to occur following several conditions: exposure to cold, physical exercise (March hemoglobinuria), ingestion of the fava bean, and in chronic hemolytic anemia (syndrome of Marchia Fava-Michaeli). Gull1 in 1866 first noted the relation of the exposure to cold to this syndrome, and in 1880 Rosenbach1 demonstrated an
DAVIS JP, ROSENBAUM D. COLD AUTOHEMOLYSIS ASSOCIATED WITH RAYNAUD'S SYNDROME: REPORT OF CASE1. Ann Intern Med. ;30:681–691. doi: 10.7326/0003-4819-30-3-681
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Published: Ann Intern Med. 1949;30(3):681-691.
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