MILTON S. SACKS
The introduction in 1935 of the sulfonamide group of drugs1 opened a new era of chemotherapeutic endeavor. In 1940 the publication of the Woods-Fildes theory2 provided not only a satisfactory explanation of the mode of action of these drugs but also a highly important basis for a rational extension of chemotherapeutic research. The basis of the theory was the principle of the biological competition of structurally related compounds. The para-amino benzoic acid-sulfonamide relationship admirably exemplifies this concept.
Woods reported that yeast extracts contained a substance which reversed the inhibitory action of sulfanilamide on the growth of hemolytic streptococci. This substance
SACKS MS. BIOLOGICAL COMPETITION BETWEEN STRUCTURALLY RELATED COMPOUNDS: CLINICAL IMPLICATIONS. Ann Intern Med. ;30:867–870. doi: 10.7326/0003-4819-30-4-867
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Published: Ann Intern Med. 1949;30(4):867-870.
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