F. C. COLEMAN, M.D.
The identification of dicoumarol as the cause of sweet clover disease was made by Link in 1939. This disease is a hemorrhagic disease in cattle which have eaten spoiled sweet clover, and is due to a decrease in the prothrombin content of the blood. In 1941 Link reported the synthesis of dicoumarol. It could be prepared in large quantities at low cost. Within three months the first published report of its clinical use was made by Allen, Barker and Waugh. It is of therapeutic value in those diseases where intravascular clotting is present. These are, particularly, thrombosis and embolism following
F. C. COLEMAN. THE PROTHROMBIN TIME IN DICOUMAROL THERAPY(THE PROTHROMBIN TIME IN DICOUMAROL THERAPY*). Ann Intern Med. 1949;30:895–902. doi: 10.7326/0003-4819-30-5-895
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Published: Ann Intern Med. 1949;30(5):895-902.
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