LOUIS W. GRANIRER
The investigation here reported was undertaken to ascertain whether or not there was any abnormal excretion of creatine in rheumatoid and osteoarthritis. Within the last decade, creatine metabolism has been the object of very extensive research. The mechanism of the intermediate metabolism of creatine has not yet been elucidated completely. Evidence, however, exists to favor the view that glycine is converted to guanidinoacetic acid which is then methylated to form creatine.1 The first of these reactions probably takes place principally in the kidney and the transfer of free methyl groups occurs chiefly in the liver.
Considerable material has been gathered
GRANIRER LW. THE URINARY EXCRETION OF CREATINE IN ARTHRITIS1. Ann Intern Med. ;30:961–965. doi: 10.7326/0003-4819-30-5-961
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Published: Ann Intern Med. 1949;30(5):961-965.
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