W. E. SHUTE, B.A., M.D.; E. V. SHUTE, B.A., M.B., F.R.C.S.(C); ARTHUR VOGELSANG, B.A., M.D.
Vitamin E first came to medical notice as a preservative of precarious pregnancies, whether habitual1 or threatened abortions.2, 3 Its rôle in the maintenance of normal gestation was later emphasized with respect to premature placental detachment4 and non-eclamptic toxemias.5 Certain uses in gynecology, such as in the menopause,6, 7 in senile vulvitis8, 9, 10 and even in male sterility,11 were also reported. But, fundamentally, for the first 25 years of its existence it did justify the appellation of "fertility vitamin" which now seems so misleading.
That this vitamin played a much more significant role than this "bit part" could have
SHUTE WE, SHUTE EV, VOGELSANG A. THE PHYSIOLOGICAL AND BIOCHEMICAL BASIS FOR THE USE OF VITAMIN E IN CARDIOVASCULAR DISEASE1. Ann Intern Med. ;30:1004–1008. doi: 10.7326/0003-4819-30-5-1004
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Published: Ann Intern Med. 1949;30(5):1004-1008.
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